BIOLOGICAL STUDIES ON DIPHTHERIA TOXIN I. THE RELATION BETWEEN DLM AND DRM
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چکیده
منابع مشابه
Studies of the Activity of Diphtheria Toxin
It has been demonstrated that a saturating dose of diphtheria toxin produced a 90% inhibition of polio-virus replication in HeLa cells. This inhibition was reflected in infectious viral RNA synthesis and in mature virus production. Toxin had no direct effect on virus particles or I-RNA, and poliovirus adsorption and eclipse appeared to be carried out normally in intoxicated cells. When toxin wa...
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Extracts from HeLa cells treated with excess diphtheria toxin for several hours, until all protein synthesis has been arrested, are still able to stimulate the poly U-directed incorporation of phenylalanine into polypeptides at a moderate rate. Activity may be restored to normal levels or above by addition of a soluble enzyme fraction containing transferase II. Our results are in agreement with...
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The effect of crystalline diphtheria toxin on protein synthesis in vivo was evaluated in guinea pigs and mice. By two independent methods of analysis (microdensitometry of tissue radioautograms and radioactivity of tissue proteins), it was established that inhibition of protein synthesis was not a widespread metabolic effect of diphtheria toxin. In the sensitive guinea pig, only the heart and t...
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In this preliminary report there are presented some of the results obtained from crossing mice from tumor strains with males from other sources. The comparison of the tumor incidence in the inbred and backcross daughters, though the numbers given are small, supports the theory that the tendency to develop neoplasms is hereditary and the frequency with which tumors appear in the first filial gen...
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phatic communion is a cultural concept which differs across cultures. according to hofstede (2001), the u.s. tends to have individualistic culture; however, asian countries tend to have collectivistic cultures. these cultures view phatic communion differently. in individualistic cultures like u.s., phatic communion reflects speakers’ socio-cultural relationships in conversations. to see whether...
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ژورنال
عنوان ژورنال: Japanese Journal of Medical Science and Biology
سال: 1960
ISSN: 0021-5112,1884-2828
DOI: 10.7883/yoken1952.13.91